How much familiarity? Most likely not much of any during your first couple of activation passes.
For example....let's use a book that would require 10 hours for you to fully comprehend with good-old regular reading.
A beginning PhotoReader will achieve the same comprehension within 3 hours or less. Now, you may go 2 hours and 59 minutes feeling like you are getting absolutely nothing from the book. But then, all of the sudden the entire book "gels" and you fully comprehend it.
The more books you PhotoRead and activate fully, the less and less time it will take to reach the "gel" point.