For some books the answer will be yes for others no. Textbooks you are often expected to read three times to get the full understanding that the teacher/lecturer expects for the course.
It doesn't hurt to PhotoRead a couple of times if you are having trouble getting in tune with a purpose for reading.
If you find activation difficult just PhotoRead the book again as part of the activation step.
Train your body mind connection to tell you if you should PhotoRead again.. yes go for it, feeling saturated or full then take that as a no and see how the activation goes when you get to activating it.
Textbooks I suggest you PhotoRead daily for a couple of weeks when you get them. It doesn't have to be all your textbooks, rotate them. It can help make the information you're learning in the class much clearer and easier to understand ... classroom activation. Means less homework later for many.
Alex