This weekend I am getting back into photoreading after a long period of ignoring it. So I am not any kind of an expert. But I have always found that my eyes don't get tired. Over the last two days I have handled about 30 books with no tiredness. The steps I followed are relax, preview, and photoread. I haven't worked on activation yet-- that's for today. (I'm mustering up my courage for that by posting here.) I don't postview right away. Perhaps I should. Anyway, the purposes I set are rather specific in terms of what I want to learn. 'Fully absorbing something and applying it' sounds a little vague to me but I'm not an expert.
As for tiredness, the previewing step, which includes looking over the book and writing down a purpose and trigger words, means a gap of several minutes between each book, so one doesn't really photoread continuously, outside of extremely long reference works I suppose. But even a long book only takes a few minutes to photoread.
Drinking water is important; I 'discovered' that long ago with my first exposure to photoreading.
Also after photoreading I find little things like, maybe I feel restless, perhaps it is harder to fall asleep promptly. It kind of shows that something is going on in the noodle.