It sounds like your set up the best you can for spouses with opposite "directions." Front door for you (day energy) and bed(evening energy)for her.
Realize there isn't a perfect feng shui option in houses, and like with the rest of life, it's all about making the best with what you have.
Place you personal direction cards, activate the general space feng shui directions (levels One and Two) in your home. Look at the water dragon for your home, tweak the front door to an auspicious degree with a hexagram, etc.
Facing a disease direction during the evening doesn't cause a disease, it just doesn't support you as well as it could, so increase the support of yourself in other ways in your home. You already have the front door cheering for you!
Much Love,
Shawn