I've found that supplements work best when I've done a thorough Detox & Cleansing through whatever methods work best. In my case it was a whole year doing Colon Hydrotherapy each month and carefuly watching what I ate as well as drinking a lot of water. Before then, supplements had some effect but nothing like now.
Supplements: A Vit. B complex for improve brain and nerve function. Oils (flax, borage, hemp, etc... I recommend "Udo's Choice Oil") for improved metabolism. A potent multi-mineral (not a multi-vitamin/mineral cap). Current agricultural practices deplete the soil of minerals so we don't get it in our foods. I feel much better taking one twice a day. A green drink: Greens+, Beyond Greens, Green Magma, etc...
That's my two cents worth.
Cheers!