Try it and see what works best for you.
The conscious mind can only remember 7 plus or minus 2 bits of information. If you have 4 ideas on your mind and you collect 3 answers or core things you need to know for each question you're going to have to forget somethng. You wind up being a passive rather than active reader. You don't need to pass throught the whole book only the sections that holds the answer.
Activation is done in layers you do as many passes as it takes to get the book to gel for you.
After each pass you check your purpose. Compare what you learned, do you want to know something more/ Did you discover something that led to another question?
It comes down to; 'what do you want to know?'
Alex